RNF103-CHMP3
Description
The RNF103-CHMP3 (RNF103-CHMP3 readthrough) is a protein-coding gene located on chromosome 2.
The RNF103-CHMP3 complex is a crucial regulator of endosomal trafficking, acting as a ubiquitin ligase to target ESCRT-III for ubiquitination. This process ensures efficient protein sorting and degradation within the endosomal pathway, playing a vital role in various cellular functions.
RNF103-CHMP3 is a protein complex that plays a crucial role in the regulation of endosomal trafficking. It acts as a ubiquitin ligase, specifically targeting the endosomal sorting complex required for transport (ESCRT)-III machinery for ubiquitination. This process is essential for proper protein sorting and degradation within the endosomal pathway, contributing to various cellular processes like protein recycling, signal transduction, and maintaining cellular homeostasis.
RNF103-CHMP3 is also known as CGI149, CHMP3, NEDF, RNF103-VPS24, VPS24, hVps24.
Associated Diseases
- progressive supranuclear palsy
- X-linked endothelial corneal dystrophy
- granular corneal dystrophy type I
- lattice corneal dystrophy type I
