RNASE1
Description
The RNASE1 (ribonuclease A family member 1, pancreatic) is a protein-coding gene located on chromosome 14.
RNASE1 is a gene that encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
RNASE1 is an endonuclease that breaks down RNA by cleaving the phosphodiester bond on the 3' side of pyrimidine nucleotides. It can act on both single-stranded and double-stranded RNA.
RNASE1 is also known as RAC1, RIB1, RNS1.
Associated Diseases
- permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome
- cancer
- COVID-19
- breast cancer
- acute kidney failure
