RIPPLY1
Description
The RIPPLY1 (ripply transcriptional repressor 1) is a protein-coding gene located on chromosome X.
RIPPLY1 plays a crucial role in somitogenesis, the process of forming the segmented blocks that make up the backbone and muscles. It acts as a repressor, silencing the genes that control segment formation in the presomitic mesoderm, effectively shutting down the segmentation program. This ensures that the formation of new segments stops at the appropriate time. RIPPLY1 also contributes to the maintenance of rostrocaudal polarity, ensuring that the segments develop in the correct head-to-tail order.
RIPPLY1 is also known as -.
Associated Diseases
- autosomal recessive spondylocostal dysostosis
- Prata-Liberal-Goncalves syndrome
- osteomesopyknosis
- Klippel-Feil syndrome 3, autosomal dominant
- colorectal cancer
- spondylocostal dysostosis
