RIPK2

Description

The RIPK2 (receptor interacting serine/threonine kinase 2) is a protein-coding gene located on chromosome 8.

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene. This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.

== Interactions == RIPK2 has been shown to interact with BIRC2.

RIPK2 is a serine/threonine/tyrosine-protein kinase that is essential for regulating both innate and adaptive immune responses. It plays a key role in the NOD1 and NOD2 signaling pathways, which are activated by bacterial peptidoglycans. When NOD1 and NOD2 are activated, they recruit RIPK2, leading to the formation of RIPK2 filaments. RIPK2 then autophosphorylates and undergoes ubiquitination, becoming a scaffolding protein for downstream effectors. This process ultimately leads to the activation of NF-κB, which regulates the transcription of genes involved in immune responses, cell growth, and apoptosis. While RIPK2 is important for NOD1 and NOD2 signaling, its kinase activity is not required for these pathways. RIPK2 also contributes to the tyrosine phosphorylation of ARHGEF2, a guanine exchange factor, which further activates NF-κB. In adaptive immunity, RIPK2 plays a role in promoting BCL10 phosphorylation and NF-κB activation upon engagement of the T-cell receptor (TCR). Additionally, RIPK2 is involved in the inactivation of RHOA in response to NGFR signaling.

RIPK2 is also known as CARD3, CARDIAK, CCK, GIG30, RICK, RIP2.

Associated Diseases

WES Whole Exome Sequencing