RIC3
Description
The RIC3 (RIC3 acetylcholine receptor chaperone) is a protein-coding gene located on chromosome 11.
RIC-3, also known as resistance to inhibitors of cholinesterase 3, is a chaperone protein encoded by the RIC3 gene in humans. The gene was first identified in C. elegans. RIC-3 protein is conserved across many animals and plays a role in the maturation of various ligand-gated ion channels, including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors, particularly the homomeric α7 nicotinic receptor. RIC-3 enhances the currents generated by these receptors by accelerating receptor transport to the cell surface and increasing receptor numbers.
RIC-3 is a molecular chaperone that facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. It may also promote functional expression of homomeric serotoninergic 5-HT3 receptors and heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2, and alpha-4/beta-4.
RIC3 is also known as AYST720, PRO1385, RIC-3.
