RHOB

Description

The RHOB (ras homolog family member B) is a protein-coding gene located on chromosome 2.

RHOB is a protein belonging to the Rho GTP-binding protein family, encoded by the RHOB gene in humans. RHOB interacts with CIT, ARHGEF3, ARHGDIG, and RHPN2.

RHOB plays a crucial role in regulating cell death, particularly in response to DNA damage in cancer cells. While not essential for normal development, RHOB influences cell adhesion and growth factor signaling in transformed cells. It acts as a tumor suppressor, as its deletion can lead to tumor formation. RHOB is involved in the movement of proteins within cells, specifically targeting PKN1 to endosomes and helping transport the EGF receptor from late endosomes to lysosomes. RHOB also contributes to the stability and movement of AKT1/AKT, which is important for the survival of endothelial cells during blood vessel development. Additionally, RHOB serves as a signal during cell division, ensuring the proper formation of the myosin contractile ring, which is essential for separating daughter cells.

RHOB is also known as ARH6, ARHB, MST081, MSTP081, RHOH6.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing