RHOA
Description
The RHOA gene provides instructions for making a protein called RhoA, a small GTPase protein that plays a crucial role in cell signaling pathways. RhoA is involved in various cellular processes, including cytoskeletal organization, cell migration, and gene expression. It acts as a molecular switch, cycling between an inactive GDP-bound state and an active GTP-bound state. When activated, RhoA triggers downstream signaling cascades that control diverse cellular functions. Dysregulation of RhoA activity can contribute to the development of various diseases.
Associated Diseases
- Cancer (e.g., colorectal cancer, breast cancer, lung cancer)
- Cardiovascular diseases (e.g., hypertension, atherosclerosis)
- Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)
- Inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease)
- Developmental disorders (e.g., intellectual disability, autism spectrum disorder)
Did you know?
RhoA is named after the Ras homology (RH) domain it contains, a protein domain found in many signaling proteins.
