RGS8
Description
The RGS8 (regulator of G protein signaling 8) is a protein-coding gene located on chromosome 1.
RGS8, encoded by the RGS8 gene, belongs to the regulator of G protein signaling (RGS) family. It features a single RGS domain and functions as a regulatory component in G protein-coupled receptor complexes. RGS proteins accelerate the cycle of GTP binding and hydrolysis to GDP, effectively terminating signal transduction. However, they also paradoxically accelerate receptor-stimulated activation.
RGS8 regulates G protein-coupled receptor signaling cascades, particularly those involving muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. It inhibits signal transduction by accelerating the GTPase activity of G protein alpha subunits, leading to their inactivation. RGS8 also modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
RGS8 is also known as -.
Associated Diseases
- schizophrenia 15
- Phelan-McDermid syndrome
- Potocki-Lupski syndrome
- Smith-Magenis syndrome
- intellectual developmental disorder, X-linked, syndromic, Pilorge type
- FRAXE intellectual disability
- cancer
