RGS4
Description
The RGS4 (regulator of G protein signaling 4) is a protein-coding gene located on chromosome 1.
RGS4, also known as RGP4, is a protein encoded by the RGS4 gene in humans. It regulates G protein signaling by acting as a GTPase activating protein (GAP) for G alpha subunits of heterotrimeric G proteins. RGS4 can deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes, driving them into their inactive GDP-bound forms. RGS4 shares a conserved 120-amino acid sequence with other RGS proteins, known as the RGS domain, which is responsible for its GAP activity. The RGS4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. It negatively regulates signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Several studies have associated the RGS4 gene with schizophrenia, although some studies have failed to detect an association.
RGS4 is also known as RGP4, SCZD9.
Associated Diseases
- schizophrenia
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- dehydrated hereditary stomatocytosis
- dominant beta-thalassemia
- hemoglobin D disease
- Potocki-Lupski syndrome
- beta-thalassemia-X-linked thrombocytopenia syndrome
- hemoglobin C-beta-thalassemia syndrome
- hereditary elliptocytosis
- hemoglobin H disease
- hemoglobin E disease
- overhydrated hereditary stomatocytosis
