RGS16
Description
The RGS16 (regulator of G protein signaling 16) is a protein-coding gene located on chromosome 1.
RGS16 is a protein encoded by the RGS16 gene in humans. It belongs to the 'regulator of G protein signaling' family and inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. This protein may also play a role in regulating the kinetics of signaling in the phototransduction cascade. RGS16 interacts with GNAQ and GNAI3.
RGS16 regulates G protein-coupled receptor signaling cascades by inhibiting signal transduction. It achieves this by increasing the GTPase activity of G protein alpha subunits, leading to their inactivation by driving them into the GDP-bound state. RGS16 plays a significant role in the phototransduction cascade by controlling the duration and effective concentration of activated transducin alpha. It may also regulate both extracellular and intracellular mitogenic signals.
RGS16 is also known as A28-RGS14, A28-RGS14P, RGS-R.
Associated Diseases
- hyper-IgM syndrome type 2
- severe combined immunodeficiency due to CTPS1 deficiency
- hyper-IgE recurrent infection syndrome 5, autosomal recessive
- hyper-IgM syndrome type 5
- severe combined immunodeficiency due to CARD11 deficiency
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- MHC class II deficiency
- autoimmune lymphoproliferative syndrome type 2B
- cancer
- immunodeficiency 96
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
