RGS12
Description
The RGS12 (regulator of G protein signaling 12) is a protein-coding gene located on chromosome 4.
RGS12 is a protein encoded by the RGS12 gene in humans. It belongs to the 'regulator of G protein signaling' (RGS) gene family and functions as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. RGS12 potentially plays a role in tumorigenesis. Multiple transcript variants, encoding distinct isoforms, have been identified for this gene. Other alternative splice variants have been described but their biological nature remains unclear. RGS12 has been shown to interact with GNAI1, GNAI3, and the kappa opioid receptor.
RGS12 regulates G protein-coupled receptor signaling cascades by enhancing the GTPase activity of G protein alpha subunits. This action leads to the inactivation of the alpha subunits, driving them into their GDP-bound form, and effectively inhibiting signal transduction.
RGS12 is also known as -.
