RGS10
Description
The RGS10 (regulator of G protein signaling 10) is a protein-coding gene located on chromosome 10.
Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene. RGS family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. They deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes, driving G proteins into their inactive GDP-bound forms. RGS10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. RGS10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. RGS10 has been shown to interact with SAP18 and GNAI3.
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein.
RGS10 is also known as -.
Associated Diseases
- type 2 diabetes mellitus
- type 1 diabetes mellitus
- diabetes mellitus, transient neonatal, 2
- hyperinsulinism due to glucokinase deficiency
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- diabetes mellitus, permanent neonatal 4
- exercise-induced hyperinsulinism
- diabetes mellitus, transient neonatal, 3
