RGS1
Description
The RGS1 (regulator of G protein signaling 1) is a protein-coding gene located on chromosome 1.
RGS1 is a protein encoded by the RGS1 gene in humans. It belongs to the regulator of G-protein signaling family. Located on the cytosolic side of the plasma membrane, RGS1 contains a conserved 120 amino acid motif known as the RGS domain. RGS1 attenuates G-protein signaling by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP). This activity increases the rate of conversion of GTP to GDP, allowing the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers and terminating the signal.
RGS1 regulates G protein-coupled receptor signaling cascades, including those downstream of N-formylpeptide chemoattractant receptors and leukotriene receptors. It inhibits B cell chemotaxis toward CXCL12. RGS1 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, driving them into their inactive GDP-bound form.
RGS1 is also known as 1R20, BL34, HEL-S-87, IER1, IR20.
Associated Diseases
- multiple sclerosis
- type 1 diabetes mellitus
- systemic lupus erythematosus
- nonpapillary renal cell carcinoma
- cancer
- common variable immunodeficiency
- isolated agammaglobulinemia
- BENTA disease
- hyper-IgM syndrome type 3
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
- immunodeficiency 105
