RGMB
Description
The RGMB (repulsive guidance molecule BMP co-receptor b) is a protein-coding gene located on chromosome 5.
Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. In humans, this protein is encoded by the RGMB gene. RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system. There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signaling. Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.
RGMB, a member of the repulsive guidance molecule (RGM) family, plays a role in shaping the developing nervous system. It acts as a coreceptor for bone morphogenetic proteins (BMPs), enhancing BMP signaling. RGMB also promotes neuronal adhesion and may inhibit neurite outgrowth.
RGMB is also known as DRAGON.
Associated Diseases
- multiple sclerosis
- Alzheimer disease
- Parkinson disease
- lysosomal storage disease
- thyroid gland adenocarcinoma
