RFK
Description
The RFK (riboflavin kinase) is a protein-coding gene located on chromosome 9.
Robert Francis Kennedy (RFK) was a prominent American politician and lawyer. He served as the Attorney General of the United States from 1961 to 1964 and later as a U.S. senator from New York from 1965 until his assassination in 1968. A member of the Democratic Party, he was a leading figure in American liberalism. Born into a wealthy and politically influential family, Kennedy received his education at Harvard and the University of Virginia. After serving in the Navy, he began his career as a journalist and lawyer. He gained national prominence as the chief counsel of the Senate Labor Rackets Committee. Kennedy was closely involved in his brother John F. Kennedy's political career, managing his 1952 senatorial campaign and serving as Attorney General during his presidency. He was assassinated in 1968 while running for the Democratic presidential nomination.
RFK catalyzes the conversion of riboflavin (vitamin B2) into flavin mononucleotide (FMN), a crucial step in the synthesis of flavin adenine dinucleotide (FAD). This enzyme is essential for the production of reactive oxygen species (ROS) triggered by tumor necrosis factor (TNF). RFK interacts with both TNFRSF1A and CYBA, physically linking TNFRSF1A to NADPH oxidase. TNF activates RFK, which promotes FAD incorporation into NADPH oxidase, a vital process for NADPH oxidase assembly and activation.
RFK is also known as RIFK.
