RFC5
Description
The RFC5 (replication factor C subunit 5) is a protein-coding gene located on chromosome 12.
Replication factor C subunit 5 is a protein encoded by the RFC5 gene in humans. It is part of the Replication factor C (RFC) complex, which is essential for DNA replication. RFC is composed of five subunits (140, 40, 38, 37, and 36 kDa), and RFC5 corresponds to the 36 kDa subunit. RFC5 interacts with the C-terminal region of proliferating cell nuclear antigen (PCNA), a protein that helps to stabilize DNA polymerase during replication. RFC5 forms a core complex with the 38 and 40 kDa subunits, which exhibits DNA-dependent ATPase activity. This activity is stimulated by PCNA in vitro. RFC5 has been shown to interact with several other proteins involved in DNA replication, including BRD4, CHTF18, RFC2, and RFC4. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
RFC5 is also known as RFC36.
Associated Diseases
- endometrial cancer
- esophageal cancer
- familial atrial fibrillation
- Brugada syndrome
- familial sick sinus syndrome
- sinoatrial node dysfunction and deafness
- long QT syndrome 9
- long QT syndrome 5
- sick sinus syndrome 1
