RFC4
Description
The RFC4 (replication factor C subunit 4) is a protein-coding gene located on chromosome 3.
RFC4 is a protein encoded by the RFC4 gene in humans. It's a component of Replication factor C (RFC), a complex essential for DNA replication. RFC, also known as Activator 1, consists of five subunits: 140, 40, 38, 37, and 36 kDa. RFC4 is the 37 kDa subunit. RFC4, along with the 36 and 40 kDa subunits, forms a core complex with DNA-dependent ATPase activity stimulated by PCNA. This activity is crucial for DNA replication. RFC4 interacts with BRD4, CHTF18, PCNA, RFC2, RFC3, and RFC5, highlighting its role in complex protein interactions during DNA replication.
The elongation of primed DNA templates by DNA polymerase delta and epsilon necessitates the presence of proliferating cell nuclear antigen (PCNA) and activator 1, a protein complex. This subunit may play a role in the elongation of multiprimed DNA templates.
RFC4 is also known as A1, RFC37.
