RETN
The RETN Gene: Unraveling Its Role in Human Health and Disease
Description
The RETN gene (also known as the resistin gene) resides on chromosome 19q13.33 and encodes a protein called resistin. Resistin is a hormone that plays a complex role in energy metabolism and immune regulation. It is primarily secreted by adipocytes (fat cells) and immune cells, with elevated levels associated with obesity and metabolic disorders.
Associated Diseases
Dysregulation of RETN expression and function has been implicated in various human diseases, including:
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Obesity and Metabolic Syndrome: High RETN levels are strongly correlated with obesity, insulin resistance, and type 2 diabetes. It may promote inflammation, disrupt glucose homeostasis, and contribute to the development of metabolic complications.
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Cardiovascular Disease: Elevated RETN levels have been linked to increased risk of atherosclerosis, coronary artery disease, and heart failure. It may promote platelet aggregation, endothelial dysfunction, and vascular remodeling.
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Immune Disorders: Resistin has immune-modulatory properties and its dysregulation has been associated with autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. It may contribute to chronic inflammation and tissue damage.
Did you Know ?
- Individuals with obesity have approximately 5-fold higher RETN levels compared to lean individuals. This strong association highlights the significant role of RETN in weight regulation and metabolic health.
