REN : renin

Description

The REN (renin) is a protein-coding gene located on chromosome 1.

The REN gene provides instructions for making renin, a protein produced in the kidneys. Renin is a key component of the renin-angiotensin system, which regulates blood pressure and fluid/salt balance. It converts angiotensinogen into angiotensin I, initiating a chain reaction leading to vasoconstriction (blood vessel narrowing) and increased blood pressure. Additionally, renin stimulates aldosterone production, causing the kidneys to absorb more water and salt, further elevating blood pressure. Proper blood pressure during fetal development is crucial for normal kidney development, particularly the proximal tubules. Angiotensin II may also directly influence kidney development by affecting growth factors involved in the development of kidney structures.

REN is also known as ADTKD4, HNFJ2, RTD.

Associated Diseases

• Tubulointerstitial kidney disease, autosomal dominant, 4
• Renal tubular dysgenesis
• REN-related kidney disease