REL
Description
The REL gene encodes a protein that belongs to the Rel family of transcription factors, which play a crucial role in regulating immune responses and cell growth. The REL protein is a subunit of the nuclear factor-kappa B (NF-κB) transcription factor complex, which is activated in response to various stimuli, including inflammation, infection, and stress. Upon activation, NF-κB translocates to the nucleus and regulates the expression of target genes involved in immune responses, inflammation, cell survival, and proliferation.
Associated Diseases
- Autoimmune diseases (e.g., rheumatoid arthritis, lupus)
- Cancer (e.g., lymphoma, leukemia)
- Inflammatory bowel disease
- Infections
Did you know?
Mutations in the REL gene have been linked to increased susceptibility to certain infections, suggesting a crucial role of REL in host defense.
