REG3G

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Description

The REG3G (regenerating family member 3 gamma) is a protein-coding gene located on chromosome 2.

Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene. Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.

REG3G is also known as LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429.

Associated Diseases

• endometrial cancer
• type 2 diabetes mellitus
• type 1 diabetes mellitus
• diabetes mellitus, transient neonatal, 2
• hypertriglyceridemia 2
• cholesterol-ester transfer protein deficiency
• thyroid hormone metabolism, abnormal, 2
• sitosterolemia
• homozygous familial hypercholesterolemia
• neonatal intrahepatic cholestasis due to citrin deficiency
• hyperinsulinism due to glucokinase deficiency
• familial apolipoprotein C-II deficiency