RDH16
Description
The RDH16 (retinol dehydrogenase 16) is a protein-coding gene located on chromosome 12.
Retinol dehydrogenase 16 (all-trans) is a protein that in humans is encoded by the RDH16 gene. The gene is also known as RODH-4 and SDR9C8.
RDH16 is an oxidoreductase that preferentially uses NAD as a cofactor. It catalyzes the oxidation of various retinoids, including all-trans-retinol, 9-cis-retinol, 11-cis-retinol, and 13-cis-retinol, to their corresponding aldehydes. RDH16 exhibits higher activity towards retinol bound to cellular retinol-binding protein (CRBP) than free retinol. Additionally, it oxidizes 3-alpha-hydroxysteroids, such as androstanediol and androsterone, to dihydrotestosterone and androstanedione. RDH16 is also capable of catalyzing the reverse reaction.
RDH16 is also known as RODH-4, RODH4, SDR9C8, hRDH-E.
Associated Diseases
- allergic disease
- thrombocythemia 2
- macrothrombocytopenia, isolated, 2, autosomal dominant
- familial isolated congenital asplenia
- thrombocytopenia 4
- primary familial polycythemia due to EPO receptor mutation
- autosomal dominant macrothrombocytopenia
- colorectal cancer
- thrombocytopenia 7
- erythrocytosis, familial, 6
