RDH13
Description
The RDH13 (retinol dehydrogenase 13) is a protein-coding gene located on chromosome 19.
Retinol dehydrogenase 13 (all-trans/9-cis) is a protein encoded by the RDH13 gene in humans. This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternative spliced transcript variants have been described.
The human RDH13 gene is located on chromosome 19, specifically at 19q13.42. It contains 12 exons in total.
Analysis suggests RDH13 associates with the inner mitochondrial membrane. Its primary structure includes two hydrophobic segments that could function as transmembrane segments; however, the protein is easily removed from the membrane by alkaline extraction, indicating it is a peripheral membrane protein. This distinguishes it from microsomal retinaldehyde reductases, which are integral membrane proteins anchored by their N-terminal hydrophobic segments.
RDH13 is most closely related to the NADP+-dependent microsomal enzymes RDH11, RDH12 and RDH14.
RDH13 is also known as SDR7C3.
