RCCD1
Description
The RCCD1 (RCC1 domain containing 1) is a protein-coding gene located on chromosome 15.
RCCD1 plays a crucial role in the transcriptional repression of satellite repeats, potentially through regulating H3K36 methylation levels in centromeric regions alongside KDM8. It also collaborates with KDM8 in ensuring proper mitotic spindle organization and chromosome segregation. Additionally, RCCD1 regulates alpha-tubulin deacetylation and cytoskeletal microtubule stability, promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT). This may be achieved through the inhibition of KDM8.
RCCD1 is also known as -.
Associated Diseases
- type 2 diabetes mellitus
- cancer
- tibia, hypoplasia or aplasia of, with polydactyly
- syndactyly type 4
- spondyloepimetaphyseal dysplasia, Missouri type
- Blount disease
- fibular aplasia-ectrodactyly syndrome
- acromesomelic dysplasia 2C, Hunter-Thompson type
- Gollop-Wolfgang complex
- laurin-Sandrow syndrome
