RCAN3
Description
The RCAN3 (RCAN family member 3) is a protein-coding gene located on chromosome 1.
RCAN3 is a gene that encodes the Calcipressin-3 protein in humans. Calcipressin-3 is a member of the Calcipressin family of proteins. RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the esophagus. RCAN3 has orthologs in other species, including mice, chickens, and zebrafish, indicating its presence in the common ancestor of all animals. Calcipressin-3, along with the other two Calcipressin proteins, have been identified as possible contributing factors to Down Syndrome in humans.
RCAN3 is also known as DSCR1L2, MCIP3, RCN3, hRCN3.
Associated Diseases
- familial atrial fibrillation
- Brugada syndrome
- sinoatrial node dysfunction and deafness
- Jervell and Lange-Nielsen syndrome 1
- Jervell and Lange-Nielsen syndrome 2
- Brugada syndrome 9
- familial sick sinus syndrome
- Brugada syndrome 3
- long QT syndrome 10
- long QT syndrome 14
