RBPMS
Description
The RBPMS (RNA binding protein, mRNA processing factor) is a protein-coding gene located on chromosome 8.
RBPMS (RNA-binding protein with multiple splicing) is a protein encoded by the RBPMS gene in humans. It belongs to the RRM family of RNA-binding proteins, characterized by a conserved RRM domain. RBPMS contains a single RRM domain in its N-terminus. Alternative splicing generates multiple transcript variants encoding different isoforms. RBPMS is uniquely expressed in retinal ganglion cells in the mammalian retina. It has been shown to interact with the protein SMUG1.
RBPMS, also known as RBP-MS or Heart and RRM expressed sequence, is an RNA-binding protein that plays a crucial role in regulating pre-mRNA alternative splicing (AS). It can act as both an activator and repressor of splicing events on specific pre-mRNA targets. RBPMS binds to introns, exons, and 3'-UTRs containing tandem CAC trinucleotide motifs separated by a variable spacer region, typically as a dimer. The minimal length of RNA required for RBPMS binding is 15 nucleotides with spacing ranging from 1 to 9 nucleotides. It can also bind to CA dinucleotide repeats. RBPMS has been shown to repress TPM1 exon 3 by binding to CAC tandem repeats in flanking intronic regions, followed by higher-order oligomerization and interactions with other splicing regulators like MBNL1 and RBFOX2. These interactions prevent the assembly of ATP-dependent splicing complexes. RBPMS contributes to the activation of a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of pre-mRNAs involved in actin cytoskeleton and focal adhesion machineries, potentially promoting a cell differentiated state.
RBPMS is also known as HERMES.
