RBM25
Description
The RBM25 (RNA binding motif protein 25) is a protein-coding gene located on chromosome 14.
RNA-binding protein 25 is a protein that in humans is encoded by the RBM25 gene.
RBM25 plays a crucial role in regulating alternative splicing of pre-mRNA, impacting the expression of various proteins. It particularly influences the expression of BCL2L1 isoforms, which are involved in apoptotic cell death. RBM25 modulates the ratio of pro-apoptotic BCL2L1 isoform S to anti-apoptotic BCL2L1 isoform L, promoting the production of isoform S when overexpressed and favoring isoform L when depleted. This regulation occurs through binding to the 5'-CGGGCA-3' RNA sequence within the BCL2L1 pre-mRNA, impacting the selection of the 5' splice site. Additionally, RBM25 interacts with LUC7L3, enhancing U1 snRNP binding to weak 5' splice sites in a 5'-CGGGCA-3'-dependent manner. Beyond its role in BCL2L1 splicing, RBM25 is implicated in the generation of an abnormal and truncated splice form of SCN5A, associated with heart failure.
RBM25 is also known as NET52, RED120, RNPC7, S164, Snu71, fSAP94.
