RBM14

Description

The RBM14 (RNA binding motif protein 14) is a protein-coding gene located on chromosome 11.

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene. RBM14 has been shown to interact with TARBP2.

RBM14 isoform 1 acts as a nuclear receptor coactivator, boosting transcription through other coactivators like NCOA6 and CITED1. Isoform 2 functions as a transcriptional repressor, modulating the activity of coactivators including isoform 1, NCOA6, and CITED1. It regulates centriole biogenesis by suppressing the formation of abnormal centriolar protein complexes in the cytoplasm, thus maintaining mitotic spindle integrity. It prevents the formation of the STIL-CENPJ complex, which can induce abnormal centriolar protein complexes, by interfering with the interaction of STIL with CENPJ. RBM14 plays a role in regulating the DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, which serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. It is also involved in regulating pre-mRNA alternative splicing.

RBM14 is also known as COAA, PSP2, SIP, SYTIP1, TMEM137.

Associated Diseases

• hypertriglyceridemia 2
• cholesterol-ester transfer protein deficiency
• thyroid hormone metabolism, abnormal, 2
• sitosterolemia
• homozygous familial hypercholesterolemia
• hypercholesterolemia, autosomal dominant, 3
• hyperlipoproteinemia type V
• hyperlipidemia due to hepatic triglyceride lipase deficiency
• hypercholesterolemia, autosomal dominant, type B
• pancreatic triacylglycerol lipase deficiency
• familial apolipoprotein C-II deficiency
• major depressive disorder
• glycogen storage disease VI
• asthma