RBBP4
Description
The RBBP4 (RB binding protein 4, chromatin remodeling factor) is a protein-coding gene located on chromosome 1.
RBBP4 is a ubiquitously expressed nuclear protein involved in histone acetylation and chromatin assembly. It is a component of several protein complexes, including the Mi-2/NuRD complex, which is involved in chromatin remodeling and transcriptional repression. RBBP4 also plays a role in corepressor complexes and binds directly to the retinoblastoma protein to regulate cell proliferation. Reduced RBBP4 levels in the hippocampus are suspected to contribute to memory loss in aging. Lower levels of RBBP4 are observed in aging humans and mice, and a dominant negative form of RBBP4 causes memory deficits in young mice.
RBBP4 is a core histone-binding subunit that can direct chromatin assembly factors, chromatin remodeling factors, and histone deacetylases to their histone substrates. This targeting process is regulated by nucleosomal DNA. RBBP4 is a component of several complexes that regulate chromatin metabolism, including the chromatin assembly factor 1 (CAF-1) complex, the core histone deacetylase (HDAC) complex, the nucleosome remodeling and histone deacetylase complex (NuRD complex), the PRC2 complex, and the NURF (nucleosome remodeling factor) complex.
RBBP4 is also known as NURF55, RBAP48, lin-53.
Associated Diseases
- cancer
- ovarian cancer
- esophageal cancer
- glioblastoma
- syndactyly type 4
- syndactyly type 5
- mesoaxial synostotic syndactyly with phalangeal reduction
- synpolydactyly type 1
- syndactyly type 1
- polydactyly of a triphalangeal thumb
- Meckel syndrome
