RBAK
RBK Gene: A Vital Regulator of Cellular Growth and Proliferation
Description
The RBK gene, also known as the RB1-inducible coiled-coil kinase, is a crucial gene involved in regulating cell growth and proliferation. It encodes a 392-amino acid protein that functions as a component of the RB1-E2F1 complex. This complex plays a central role in controlling the cell cycle by preventing the transcription of genes required for cell division until the cell is ready.
Associated Diseases
Mutations or alterations in the RBK gene have been linked to several diseases, including:
- Retinoblastoma: A rare eye cancer that occurs in children and is characterized by uncontrolled cell growth in the retina.
- Osteosarcoma: A bone cancer that is characterized by the formation of malignant cells in the bone.
- Brain tumors: RBK mutations have been implicated in certain types of brain tumors, such as medulloblastoma and glioblastoma.
- Breast cancer: Some studies have suggested that RBK alterations may contribute to the development of certain types of breast cancer.
- Ovarian cancer: Mutations in RBK have been associated with an increased risk of ovarian cancer.
Did you Know ?
- Approximately 1 in 15,000 children worldwide is born with retinoblastoma, making it one of the most common childhood cancers.
