RB1CC1
Description
The RB1CC1 (RB1 inducible coiled-coil 1) is a protein-coding gene located on chromosome 8.
RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene.
== Interactions == RB1CC1 has been shown to interact with PTK2B, ASK1 and PTK2.
RB1CC1, also known as FAK family kinase-interacting protein of 200 kDa, plays a critical role in autophagy. It regulates both early and late stages of autophagosome formation through direct interaction with Atg16L1. It is essential for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole during S.typhimurium infection, contributing to xenophagy. Furthermore, RB1CC1 is involved in the repair of DNA damage caused by ionizing radiation, enhancing cell survival by reducing apoptosis. It inhibits the kinase activity of PTK2/FAK1 and PTK2B/PYK2, impacting their downstream signaling pathways. RB1CC1 acts as a modulator of TGF-beta signaling by restricting the substrate specificity of RNF111. It functions as a DNA-binding transcription factor and is a potent regulator of the RB1 pathway through the induction of RB1 expression. RB1CC1 is crucial for muscular differentiation and plays an indispensable role in fetal hematopoiesis and neuronal homeostasis.
RB1CC1 is also known as ATG17, CC1, FIP200, PPP1R131.
