RASSF5

Description

The RASSF5 (Ras association domain family member 5) is a protein-coding gene located on chromosome 1.

RASSF5 is a protein encoded by the RASSF5 or F5 gene in humans. It belongs to the Ras association domain family and acts as a tumor suppressor, becoming inactive in various cancers. RASSF5 localizes to centrosomes and microtubules, associating with active forms of Ras, Rap1, and other Ras-like small GTPases. It regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. The gene produces multiple transcript variants that code for different isoforms. RASSF5 interacts with RRAS, RAP2A, MRAS, and RASSF1.

RASSF5 acts as a potential tumor suppressor. It plays a role in lymphocyte adhesion by connecting RAP1A activation, triggered by T-cell receptor or chemokine stimulation, to integrin activation. Isoform 2 enhances lymphocyte polarization and the clustered distribution of ITGAL/LFA-1, leading to stronger adhesion to ICAM1. Collaborating with RAP1A, RASSF5 might participate in regulating microtubule growth. The association of isoform 2 with activated RAP1A is essential for the directed movement of endothelial cells during wound healing. RASSF5 may be involved in regulating Ras-mediated apoptosis. The RASSF5-STK4/MST1 complex could mediate apoptosis induced by HRAS and KRAS.

RASSF5 is also known as Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3.

Associated Diseases

WES Whole Exome Sequencing