RASIP1
Description
The RASIP1 (Ras interacting protein 1) is a protein-coding gene located on chromosome 19.
RASIP1, also known as Rain, is a protein encoded by the RASIP1 gene in humans. It is crucial for proper vascular development, playing a role in both vasculogenesis and angiogenesis. RASIP1 acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which are essential for endothelial cell morphogenesis and blood vessel formation. RASIP1 regulates the activity of Rho GTPases by recruiting ARHGAP29 and suppressing RhoA signaling, dampening ROCK and MYH9 activities in endothelial cells. A recent genome-wide association study (GWAS) has linked genetic variations in RASIP1 to late-onset sporadic Alzheimer’s disease (LOAD), but the specific mechanism by which RASIP1 mutations contribute to the disease remains unknown.
RASIP1 is essential for proper vascular structure formation, playing a role in both vasculogenesis and angiogenesis. It acts as a key regulator of GTPase signaling, cell architecture, and adhesion, critical for endothelial cell morphogenesis and blood vessel tubulogenesis. RASIP1 regulates Rho GTPases by recruiting ARHGAP29, suppressing RhoA signaling, and dampening ROCK and MYH9 activities in endothelial cells. It may also function as an effector for Golgi-bound HRAS and other Ras-like proteins, potentially promoting HRAS-mediated transformation. Furthermore, RASIP1 acts as a negative regulator of amino acid starvation-induced autophagy.
RASIP1 is also known as RAIN.
