RASGRF1
Description
The RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1) is a protein-coding gene located on chromosome 15.
RASGRF1 is a human gene that encodes a protein called Ras protein-specific guanine nucleotide-releasing factor 1. This protein acts as a guanine nucleotide exchange factor (GEF), similar to the CDC25 gene product found in yeast. It stimulates the release of GDP from the Ras protein, activating its signaling function. Research on the similar gene in mice suggests that the activity of RASGRF1 in the brain can be triggered by calcium influx, muscarinic receptors, and G protein beta-gamma subunits. These studies also indicate that the Ras-GEF signaling pathway mediated by RASGRF1 might be essential for long-term memory. Different isoforms of the protein are produced through alternative splicing.
RASGRF1 facilitates the replacement of GDP bound to Ras with GTP.
RASGRF1 is also known as CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1.
