RARRES1
Description
The RARRES1 (retinoic acid receptor responder 1) is a protein-coding gene located on chromosome 3.
Retinoic acid receptor responder protein 1 is a protein encoded by the RARRES1 gene in humans. It was identified as a retinoid acid (RA) receptor-responsive gene and encodes a type 1 membrane protein. Its expression is upregulated by tazarotene and retinoic acid receptors. Expression is downregulated in prostate cancer due to methylation of its promoter and CpG island. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
RARRES1 is also known as LXNL, PERG-1, TIG1.
Associated Diseases
- cancer
- leukemia, acute, X-linked
- common variable immunodeficiency
- classic Hodgkin lymphoma
- isolated agammaglobulinemia
