RARA-AS1
Description
The RARA-AS1 (RARA antisense RNA 1) is a ncRNA gene located on chromosome 17.
RARA-AS1 is a long non-coding RNA (lncRNA) that is transcribed from the opposite strand of the retinoic acid receptor alpha (RARA) gene. It acts as a molecular sponge for microRNAs (miRNAs), specifically miR-145, which regulates RARA expression. RARA-AS1 is involved in various cellular processes, including cell growth, differentiation, and apoptosis, and its dysregulation is associated with cancer development.
RARA-AS1, also known as the retinoic acid receptor alpha antisense RNA 1, is a long non-coding RNA (lncRNA) that plays a crucial role in regulating the expression of the retinoic acid receptor alpha (RARA) gene. This lncRNA functions as a molecular sponge for microRNAs (miRNAs) by binding to them and preventing their interaction with target mRNAs. Specifically, RARA-AS1 has been shown to interact with miR-145, which is a known regulator of RARA expression. By sequestering miR-145, RARA-AS1 indirectly enhances the expression of RARA. Furthermore, RARA-AS1 has been implicated in various cellular processes, including cell growth, differentiation, and apoptosis. Its expression has been linked to the development of certain cancers, including acute promyelocytic leukemia (APL) and breast cancer. Dysregulation of RARA-AS1 expression can lead to abnormal cellular behavior and contribute to disease progression.
RARA-AS1 is also known as -.
