RAI14
The RAI14 Gene: Unveiling its Role in Health and Disease
Description
RAI14 (Retinoic Acid Inducible 14) is a gene located on chromosome 17p13.1. It encodes a protein involved in various cellular processes, including transcriptional regulation, cell cycle progression, and DNA damage response.
Associated Diseases
Mutations or dysregulation of the RAI14 gene have been linked to several diseases:
- Acute myeloid leukemia (AML): Loss-of-function mutations in RAI14 are associated with increased risk of AML, particularly in patients with the t(8;21)(q22;q22) chromosomal translocation.
- Myelodysplastic syndromes (MDS): RAI14 mutations can also contribute to the development of MDS, a group of blood disorders characterized by abnormal blood cell production.
- Cancer metastasis: RAI14 has been implicated in cancer metastasis by promoting epithelial-mesenchymal transition (EMT), a process that allows cancer cells to gain invasive characteristics.
- Neurodegenerative diseases: Recent studies suggest that RAI14 may play a role in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Did you Know ?
- According to the National Cancer Institute, RAI14 mutations occur in approximately 10-20% of AML cases.
