RAET1K
Description
The RAET1K (retinoic acid early transcript 1K (pseudogene)) is a pseudo gene located on chromosome 6.
RAET1K, also known as ULBP2, is a protein that in humans is encoded by the RAET1K gene. RAET1K is a type I transmembrane protein and a member of the NKG2D ligand family. RAET1K is expressed on various cell types including epithelial cells, endothelial cells, and fibroblasts. RAET1K binds to the NKG2D receptor on NK cells and CD8+ T cells, triggering their activation and leading to the elimination of the target cells. This process contributes to the control of viral infections, tumor surveillance, and immune homeostasis. RAET1K expression is often downregulated in cancer cells, allowing them to evade immune detection. Therefore, RAET1K has emerged as a potential target for cancer immunotherapy.
RAET1K, also known as ULBP2, is a type I transmembrane protein belonging to the NKG2D ligand family. It is expressed on various cell types, including epithelial cells, endothelial cells, and fibroblasts, and plays a role in the immune response by activating NK cells and CD8+ T cells. When expressed on stressed or tumor cells, RAET1K binds to the NKG2D receptor on NK cells and CD8+ T cells, triggering their activation and leading to the elimination of the target cells. This process contributes to the control of viral infections, tumor surveillance, and immune homeostasis. RAET1K expression is often downregulated in cancer cells, allowing them to evade immune detection. Therefore, RAET1K has emerged as a potential target for cancer immunotherapy.
RAET1K is also known as -.
