RAD54B
Description
The RAD54B (RAD54 homolog B) is a protein-coding gene located on chromosome 8.
RAD54B is a human protein encoded by the RAD54B gene. It belongs to the DEAD-like helicase superfamily and is involved in homologous recombination and DNA repair. RAD54B binds to double-stranded DNA and displays ATPase activity in the presence of DNA. It is highly expressed in testis and spleen, suggesting active roles in meiotic and mitotic recombination. Mutations in RAD54B have been linked to primary lymphoma and colon cancer. RAD54B interacts with RAD51. Somatic mutations or deletions in the RAD54B gene are found in various cancers, including colorectal cancer, breast cancer, and lung cancer. These cancers account for around 20,500 diagnoses annually in North America. Pre-clinical studies have shown that colon cancer cells deficient in RAD54B are vulnerable to PARP1 inhibitors. This suggests that targeting PARP1 may be an effective treatment strategy for cancers with RAD54B deficiencies.
RAD54B is also known as RDH54.
