RAD21L1
Description
The RAD21L1 (RAD21 cohesin complex component like 1) is a protein-coding gene located on chromosome 20.
RAD21L1 is a meiosis-specific component of certain cohesin complexes crucial for the initial stages of prophase I in male meiosis. Its presence in early meiosis is thought to be essential for the separation of sister chromatids and homologous chromosomes. During premeiotic S phase, RAD21L1 replaces RAD21, a cohesin component, while RAD21 returns later in prophase I. RAD21L1 is involved in the formation of the synaptonemal complex, initiating synapsis and crossover recombination between homologous chromosomes during prophase I.
RAD21L1 is also known as RAD21L, dJ545L17.2.
Associated Diseases
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure 73
- spermatogenic failure 74
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure, X-linked, 2
- spermatogenic failure 61
- spermatogenic failure 48
- spermatogenic failure 20
- isochromosomy Yp
- spermatogenic failure 72
- spermatogenic failure 46
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure, X-linked, 3
- spermatogenic failure 43
- spermatogenic failure 45
- spermatogenic failure 19
- spermatogenic failure 49
- spermatogenic failure 65
- spermatogenic failure 40
