RAC3
Description
The RAC3 (Rac family small GTPase 3) is a protein-coding gene located on chromosome 17.
RAC3 (Ras-related C3 botulinum toxin substrate 3) is a human gene that encodes a G protein. RAC3 is a critical component of intracellular signaling pathways and belongs to the Rac subfamily of the Rho family of small G proteins. These proteins are known to regulate a variety of cellular events, including cell growth control, cytoskeletal reorganization, and the activation of protein kinases. RAC3 has been shown to interact with proteins such as CIB1, HNF1A, Nrf2, ETAR, ILK, and β-arr1. The RAC3 gene is located on chromosome 17, in the third sub-band of the fifth band in the second region of the q arm. Several tumor suppressor genes are located near the RAC3 gene. RAC3 is overexpressed in carcinoma cells, making it a potential therapeutic target for treating cancers such as lung adenocarcinoma. Epithelial cells undergo a transformation into mesenchymal cells during invasion, and this transformation is regulated by the RAC3 gene.
RAC3 is a small GTPase that is located on the plasma membrane and cycles between an active GTP-bound and inactive GDP-bound state. When active, RAC3 binds to various effector proteins, which regulate cellular processes such as cell spreading and the formation of actin-based protrusions like lamellipodia and membrane ruffles. RAC3 also promotes cell adhesion and spreading on fibrinogen through a mechanism involving CIB1 and alpha-IIb/beta3 integrin.
RAC3 is also known as -.
