RAC1
Description
The RAC1 gene provides instructions for making a protein called Rac1, a small GTPase that plays a critical role in cell signaling. Rac1 acts as a molecular switch, cycling between an active and inactive state, and its activation triggers a cascade of downstream signaling events. These events regulate a wide range of cellular processes, including cell growth, survival, movement, and adhesion. Mutations in the RAC1 gene can lead to various diseases, highlighting its crucial role in maintaining cellular homeostasis.
Associated Diseases
- Cancer (e.g., melanoma, breast cancer, lung cancer)
- Neurodevelopmental disorders (e.g., autism spectrum disorder)
- Immune disorders (e.g., autoimmune diseases)
- Cardiovascular diseases (e.g., atherosclerosis)
- Developmental defects (e.g., craniofacial abnormalities)
Did you know?
RAC1 is involved in the formation of lamellipodia, finger-like projections that enable cells to move and migrate.
