RAB25
Description
The RAB25 (RAB25, member RAS oncogene family) is a protein-coding gene located on chromosome 1.
RAB25 is a protein that is encoded by the RAB25 gene in humans. It is thought to act as a promoter of tumor development. RAB25 has been shown to interact with RAB11FIP2 and RAB11FIP5.
RAB25 is involved in the regulation of cell survival. It promotes invasive migration of cells by localizing and maintaining integrin alpha-V/beta-1 at the tips of extending pseudopodia. RAB25 also plays a role in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. It may selectively regulate the apical recycling pathway and, together with MYO5B, regulates transcytosis.
RAB25 is also known as CATX-8, RAB11C.
Associated Diseases
- breast cancer
- cancer
- nonpapillary renal cell carcinoma
- esophageal cancer
- atresia of small intestine
- multiple intestinal atresia
- hereditary leiomyomatosis and renal cell cancer
- duodenal atresia
- familial visceral myopathy
- 46,XX ovotesticular disorder of sex development
