RAB21
Description
The RAB21 (RAB21, member RAS oncogene family) is a protein-coding gene located on chromosome 12.
Ras-related protein Rab-21 is a protein that in humans is encoded by the RAB21 gene.
RAB21 is a small GTPase that plays a role in membrane trafficking control, specifically regulating the endosomal trafficking of integrins during mitosis of adherent cells, which is crucial for successful cytokinesis. It also controls integrin internalization and recycling without affecting the general trafficking of endosomally translocated receptors. This suggests a role in regulating cell adhesion and migration. RAB21 is involved in neurite growth and, upon activation by SBF2/MTMT13 in response to starvation-induced autophagy, binds to and regulates VAMP8 endolysosomal transport, which is essential for autophagosome-lysosome fusion. It modulates the protein levels of cargo receptors TMED2 and TMED10 and is necessary for the proper Golgi localization of TMED10. RAB21 interacts with the cytoplasmic tail of various integrins, RABGEF1, ANKRD27, VAMP7, and VAMP8 in a GTP-bound state, suggesting a role in regulating VAMP8 endolysosomal trafficking and TMED10 abundance and localization at the Golgi.
RAB21 is also known as -.
