RAB1A
Description
The RAB1A (RAB1A, member RAS oncogene family) is a protein-coding gene located on chromosome 2.
RAB1A is a protein that is encoded by the RAB1A gene in humans. It is a member of the Ras-related protein Rab family, which are key regulators of intracellular membrane trafficking.
RAB1A is a small GTPase that plays a key role in regulating intracellular membrane trafficking, particularly in the movement of vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus and to the cell surface. It cycles between an inactive GDP-bound form and an active GTP-bound form, which allows it to recruit different sets of downstream effectors that control vesicle formation, movement, tethering, and fusion. RAB1A is involved in IL-8 and growth hormone secretion, maintaining the compacted morphology of the Golgi, regulating the level of CASR at the cell membrane, and playing roles in cell adhesion, cell migration, autophagosome assembly, and cellular defense against bacteria. Additionally, it plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
RAB1A is also known as RAB1, YPT1.
