RAB14
Description
The RAB14 (RAB14, member RAS oncogene family) is a protein-coding gene located on chromosome 9.
Ras-related protein Rab-14 is a protein that in humans is encoded by the RAB14 gene.
RAB14 plays a crucial role in membrane trafficking between the Golgi complex and endosomes during early embryonic development. It regulates the transport of FGFR-containing vesicles from the Golgi to endosomes, a vital process for the formation of the basement membrane, epiblast, and primitive endoderm lineages during early postimplantation development. RAB14 may achieve this by modulating the association of the kinesin KIF16B with cargo on endosomes. In collaboration with its guanine nucleotide exchange factor DENND6A, RAB14 regulates the specific endocytic transport of ADAM10, leading to the shedding of N-cadherin/CDH2 and influencing cell-cell adhesion.
RAB14 is also known as FBP, RAB-14.
