RAB12
Description
The RAB12 (RAB12, member RAS oncogene family) is a protein-coding gene located on chromosome 18.
RAB12 is a human gene that encodes a protein involved in regulating intracellular membrane trafficking. It is a small GTPase protein that cycles between an inactive GDP-bound state and an active GTP-bound state, allowing it to recruit specific effector proteins involved in vesicle formation, movement, tethering, and fusion. RAB12 is thought to be involved in the transport of proteins from recycling endosomes to lysosomes, and it may play a role in autophagy.
RAB12, a small GTPase belonging to the Rab family, plays a crucial role in regulating intracellular membrane trafficking. It cycles between an inactive GDP-bound state and an active GTP-bound state, which allows it to recruit specific effector proteins involved in vesicle formation, movement, tethering, and fusion. Research suggests that RAB12 might be involved in the transport of proteins from recycling endosomes to lysosomes, potentially regulating the degradation of the transferrin receptor. Additionally, it is implicated in the process of autophagy.
RAB12 is also known as -.
