RAB11FIP3

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Description

The RAB11FIP3 (RAB11 family interacting protein 3) is a protein-coding gene located on chromosome 16.

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene. Proteins of the large Rab GTPase family have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles.

RAB11FIP3, also known as Arfophilin-1, is a downstream effector molecule for Rab11 GTPase. It is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery. RAB11FIP3 is recruited by Rab11 to endosomes, where it links Rab11 to the dynein motor complex. This complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of the cell cycle. RAB11FIP3 facilitates the interaction between dynein and dynactin and activates dynein processivity. Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes. During telophase, the Rab11-RAB11FIP3 complex is implicated in the transport of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules. These vesicles deliver membrane during late cytokinesis and abscission. The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes. RAB11FIP3 is also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade, facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to the mother centriole and ciliogenesis initiation. It promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin. RAB11FIP3 competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway. RAB11FIP3 may play a role in breast cancer cell motility by regulating the actin cytoskeleton.

RAB11FIP3 is also known as CART1, FIP3, FIP3-Rab11, Rab11-FIP3.

Associated Diseases

• X-linked intellectual disability-psychosis-macroorchidism syndrome
• Alzheimer disease
• amyotrophic lateral sclerosis