RAB11FIP2
Description
The RAB11FIP2 (RAB11 family interacting protein 2) is a protein-coding gene located on chromosome 10.
RAB11FIP2 is a protein encoded by the RAB11FIP2 gene in humans. It interacts with MYO5B, RAB11A, and RAB25.
RAB11FIP2 is a Rab11 effector protein that binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). It regulates the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. RAB11FIP2 is involved in insulin granule exocytosis, receptor-mediated endocytosis, and membrane trafficking of recycling endosomes. It is required for the transport of NPC1L1 to the plasma membrane in a complex with MYO5B and RAB11. RAB11FIP2 acts as a regulator of cell polarity and plays a crucial role in phagocytosis by controlling actin dynamics through a mechanism involving TICAM2, RAC1, and CDC42 Rho GTPases.
RAB11FIP2 is also known as Rab11-FIP2, nRip11.
