RAB10
Description
The RAB10 (RAB10, member RAS oncogene family) is a protein-coding gene located on chromosome 2.
Ras-related protein Rab-10 is a protein that in humans is encoded by the RAB10 gene.
== Interactions == RAB10 has been shown to interact with AP1S1.
RAB10 is a small GTPase involved in regulating intracellular membrane trafficking, including vesicle formation, movement, tethering, and fusion. It plays a crucial role in the transport of proteins from the Golgi apparatus to the plasma membrane, specifically regulating the delivery of glucose transporters (SLC2A4/GLUT4) and toll-like receptor 4 (TLR4). RAB10 is also involved in asymmetric protein transport, axonogenesis, and ciliogenesis. It interacts with various proteins, including LRRK2, RILPL1, and MYO5A, and its phosphorylation by LRRK2 on Thr-73 influences its role in ciliogenesis. RAB10 also plays a role in endoplasmic reticulum dynamics and morphology, and it can interact with Legionella pneumophila during infection. {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}
RAB10 is also known as -.
